Transmembrane β-Barrels (TMBBs) are a structural class of membrane-spanning protein found in the outer membranes of Gram-negative bacteria, mitochondria and chloroplasts. As membrane proteins have proven to be difficult to characterize experimentally, computational methods have arisen to assist scientists in identifying TMBB sequences. While the amount of sequence data grows increasingly vast, computational prediction methods become increasingly more important in sifting through the copious data. accurate predictors of sequences which can adopt the TMBB structure.